Rapid diagnostic tests duo as alternative to conventional serological assays for conclusive Chagas disease diagnosis
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چکیده
منابع مشابه
Rapid diagnostic tests duo as alternative to conventional serological assays for conclusive Chagas disease diagnosis
Chagas disease is caused by the parasite Trypanosoma cruzi. It affects several million people, mainly in Latin America, and severe cardiac and/or digestive complications occur in ~30% of the chronically infected patients. Disease acute stage is mostly asymptomatic and infection goes undiagnosed. In the chronic phase direct parasite detection is hampered due to its concealed presence and diagnos...
متن کاملAssessment of chemiluminescence and PCR effectiveness in relation to conventional serological tests for the diagnosis of Chagas' disease.
While testing 414 sera for the diagnosis of Chagas' disease, the conventional reactions of indirect hemagglutination, indirect immunofluorescence and the immunosorbent assay showed a sensitivity of 95.7%, 100% and 98.2% and a specificity of 98%, 98% and 96.4%, respectively, and an excellent association using Fisher's exact test. Chemiluminescence presented 100% sensitivity and 89.6% specificity...
متن کاملPosttherapeutic cure criteria in Chagas' disease: conventional serology followed by supplementary serological, parasitological, and molecular tests.
We performed a critical study of conventional serology, followed by supplementary serological, parasitological, and molecular tests, to assess the response to etiologic treatment of Chagas' disease. A group of 94 Chagas' disease patients treated with benznidazole at least 10 years earlier were evaluated from the laboratory and clinical points of view. When conventional serology (enzyme-linked i...
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In response to the outbreak of COVID-19, caused by the SARS-CoV-2 virus, several tests are needed for diagnosis of acute illness, contact tracking, diagnosis of asymptomatic infections, and assessment of herd immunity. While PCR is the standard test in acute type, serological tests have been developed and used to meet diagnostic needs due to the widespread prevalence of the disease. Unlike the...
متن کامل[Concordance of two serological tests for the diagnosis of Chagas disease].
OBJECTIVE Establish the concordance between in-house ELISA and IIF for the diagnosis of infection with T. cruzi using blood eluates. METHODOLOGY A study of diagnostic technology evaluation and cross-sectional sample of 650 residents of an endemic area of Colombia was conducted. It was determined the Receiver Operating Characteristic curve (ROC) and IIF was used as a gold standard. It was esta...
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ژورنال
عنوان ژورنال: PLOS Neglected Tropical Diseases
سال: 2017
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0005501